Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and responses to therapy. Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention (Sergei I Grivennikov, et al. Cell. 2010 Mar 19;140(6):883-99). Acupuncture treatment regulates peripheral immunity, especially immune cells in the peripheral blood and immune cells in the spleen. And acupuncture has the potential to modulate the immune response induced by IS, which is related to its neuroprotective effects (Hongjun Kuang, et al. Front. Immunol., 01 May 2024). Acupuncture has emerged as a promising therapy to provide significant advantages for immunomodulation in acute inflammation. Acupuncture obtains its regulatory effect by activating the somatic-autonomic-immune reflexes, including the somatic-sympathetic-splenic reflex, the somatic-sympathetic-adrenal reflex, the somatic-vagal-splenic reflex and the somatic-vagal-adrenal reflex, which produces a systemic effect (Wei-Xing Pan, et al. Auton Neurosci. 2021 May:232:102793). In a scientific research review, the article hypothesizes that acupuncture stimulation enhances NK cell stimulating cytokines and NK cell anticancer cytotoxic activity and proliferation through specific cellular and molecular mechanisms, thus enhancing host resistance to cancer in both rodents and humans. Malignant tumors produce or secrete some immunosuppressive substances to evade the role of the immune system, to expect the normal growth and proliferation of tumor cells. Acupuncture has a sufficiently dual regulating effect and can improve immune function. The mechanism of tumor elimination by restoring the body’s immune ability is consistent with the concept of “nourishing positive accumulation and eliminating cancer by itself” in TCM (Na Wang, et al. Front Immunol. 2023 Feb 14;14:1092402). Acupuncture and immunotherapy, particularly in the context of cancer treatment, can be used together as complementary therapies, with acupuncture potentially enhancing the efficacy of immunotherapy. Acupuncture may help modulate the immune system, potentially increasing T cell levels and enhancing the body's response to cancer. It may also help manage side effects associated with immunotherapy Google AI Overview).